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Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation
The prevalence and dire implications of mutations in the tumour suppressor, p53, highlight its appeal as a chemotherapeutic target. We recently showed that impairing cellular antioxidant systems via inhibition of SLC7A11, a component of the system x(c)(−) cystine-glutamate antiporter, enhances sensi...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7904805/ https://ncbi.nlm.nih.gov/pubmed/33627789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83979-3 |
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