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The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress
Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR). Previous biochemical studies have shown that Ire1 exhibits strong endoribonuclease activity when its cytosolic kin...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7904763/ https://ncbi.nlm.nih.gov/pubmed/33627709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83890-x |
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