Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion

TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. In the present study, we characterized colon cancer cells (HCT116 p53 (−/−)) with TP53 deletion, a sub-line derived from HCT116-p53 (+/+) cells. RNA sequencing and net...

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發表在:Arch Toxicol
Main Authors: Kadioglu, Onat, Saeed, Mohamed, Mahmoud, Nuha, Azawi, Shaymaa, Mrasek, Kristin, Liehr, Thomas, Efferth, Thomas
格式: Artigo
語言:Inglês
出版: Springer Berlin Heidelberg 2021
主題:
Molecular Toxicology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904745/
https://ncbi.nlm.nih.gov/pubmed/33515271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-02979-4
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