Genomic and transcriptomic profiling of resistant CEM/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unravelling the full complexity of multi-factorial multidrug resistance

We systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed in vitro. RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed. Chromosomal aberr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kadioglu, Onat, Cao, Jingming, Kosyakova, Nadezda, Mrasek, Kristin, Liehr, Thomas, Efferth, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099876/
https://ncbi.nlm.nih.gov/pubmed/27824156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36754
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