Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors

Filoviridae, including Ebola (EBOV) and Marburg (MARV) viruses, are emerging pathogens that pose a serious threat to public health. No agents have been approved to treat filovirus infections, representing a major unmet medical need. The selective estrogen receptor modulator (SERM) toremifene was pre...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Cooper, Laura, Schafer, Adam, Li, Yangfeng, Cheng, Han, Fagla, Bani Medegan, Shen, Zhengnan, Nowar, Raghad, Dye, Katherine, Anantpadma, Manu, Davey, Robert A., Thatcher, Gregory R.J., Rong, Lijun, Xiong, Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904233/
https://ncbi.nlm.nih.gov/pubmed/32886512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01001
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