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When to wake up? The optimal waking-up strategies for starvation-induced persistence

Prolonged lag time can be induced by starvation contributing to the antibiotic tolerance of bacteria. We analyze the optimal lag time to survive and grow the iterative and stochastic application of antibiotics. A simple model shows that the optimal lag time can exhibit a discontinuous transition whe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Comput Biol
Prif Awduron: Himeoka, Yusuke, Mitarai, Namiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904209/
https://ncbi.nlm.nih.gov/pubmed/33571191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008655
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