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When to wake up? The optimal waking-up strategies for starvation-induced persistence

Prolonged lag time can be induced by starvation contributing to the antibiotic tolerance of bacteria. We analyze the optimal lag time to survive and grow the iterative and stochastic application of antibiotics. A simple model shows that the optimal lag time can exhibit a discontinuous transition whe...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Himeoka, Yusuke, Mitarai, Namiko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904209/
https://ncbi.nlm.nih.gov/pubmed/33571191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008655
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