Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01

Parkinson’s disease is characterized by the loss of dopaminergic neurons in the substantia nigra leading to disabling deficits. Dopamine neuron grafts may provide a significant therapeutic advance over current therapies. We have generated midbrain dopamine neurons from human embryonic stem cells and...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Piao, Jinghua, Zabierowski, Susan, Dubose, Brittany N., Hill, Ellen J., Navare, Monalisa, Claros, Nidia, Rosen, Siera, Ramnarine, Kiran, Horn, Callie, Fredrickson, Craig, Wong, Karen, Safford, Brent, Kriks, Sonja, El Maarouf, Abderrahman, Rutishauser, Urs, Henchcliffe, Claire, Wang, Yongzeng, Riviere, Isabelle, Mann, Shannon, Bermudez, Vladimir, Irion, Stefan, Studer, Lorenz, Tomishima, Mark, Tabar, Viviane
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7903922/
https://ncbi.nlm.nih.gov/pubmed/33545080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.01.004
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