Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use

Human pluripotent stem cells show considerable promise for applications in regenerative medicine including the development cell replacement paradigms for the treatment of Parkinson’s disease. Protocols have been developed to generate authentic midbrain dopamine (mDA) neurons capable of reversing dop...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Kim, Tae Wan, Piao, Jinghua, Koo, So Yeon, Kriks, Sonja, Chung, Sun Young, Betel, Doron, Socci, Nicholas D, Choi, Se Joon, Zabierowski, Susan, Dubose, Brittany N, Hill, Ellen J, Mosharov, Eugene V, Irion, Stefan, Tomishima, Mark J, Tabar, Viviane, Studer, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006469/
https://ncbi.nlm.nih.gov/pubmed/33545081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.01.005
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