DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

BACKGROUND: DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mechanisms of PRIM1 and identify it as a potential molecular target for HCC. METHOD...

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Vydáno v:Cell Biosci
Hlavní autoři: Zhu, Mengqi, Wu, Mengna, Bian, Saiyan, Song, Qianqian, Xiao, Mingbing, Huang, Hua, You, Li, Zhang, Jianping, Zhang, Jie, Cheng, Chun, Ni, Wenkai, Zheng, Wenjie
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7903777/
https://ncbi.nlm.nih.gov/pubmed/33622397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00555-y
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