TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

OBJECTIVE: Brown adipose tissue (BAT) thermogenesis offers the potential to improve metabolic health in mice and humans. However, humans predominantly live under thermoneutral conditions, leading to BAT whitening, a reduction in BAT mitochondrial content and metabolic activity. Recent studies have e...

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Vydáno v:Mol Metab
Hlavní autoři: Sass, Frederike, Schlein, Christian, Jaeckstein, Michelle Y., Pertzborn, Paul, Schweizer, Michaela, Schinke, Thorsten, Ballabio, Andrea, Scheja, Ludger, Heeren, Joerg, Fischer, Alexander W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7903014/
https://ncbi.nlm.nih.gov/pubmed/33516944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101173
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