Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer’s Disease, Without Altering Amyloid-β and Tau Pathologies

BACKGROUND: Alzheimer’s disease (AD) is a multifactorial disease, implying that multi-target treatments may be necessary to effectively cure AD. Tetrahydrobiopterin (BH4) is an enzymatic cofactor required for the synthesis of monoamines and nitric oxide that also exerts antioxidant and anti-inflamma...

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Bibliografski detalji
Izdano u:J Alzheimers Dis
Glavni autori: Fanet, Hortense, Tournissac, Marine, Leclerc, Manon, Caron, Vicky, Tremblay, Cyntia, Vancassel, Sylvie, Calon, Frédéric
Format: Artigo
Jezik:Inglês
Izdano: IOS Press 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902975/
https://ncbi.nlm.nih.gov/pubmed/33337360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200637
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