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Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy

T-cells genetically engineered to express a chimeric antigen receptor (CAR) have shown remarkable results in patients with B-cell malignancies, including B-cell acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and mantle cell lymphoma, with some promising efficacy in patients with multip...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lindo, Lorenzo, Wilkinson, Lauren Hanna, Hay, Kevin Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902760/
https://ncbi.nlm.nih.gov/pubmed/33643299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.618387
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