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Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors
Olsalazine (Olsa) is a broad-spectrum anti-cancer agent acting as a DNA methylation inhibitor. When conjugated to 2-cyano-6-aminobenzothiazole and a peptide substrate specific for the tumor-overexpressed enzyme furin, it can self-assemble into nanoparticles that can be detected by chemical exchange...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7902394/ https://ncbi.nlm.nih.gov/pubmed/33325142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202014839 |
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