Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids

In vitro cytochrome P450 inhibition of major kratom alkaloids: mitragynine (MTG), speciogynine (SPG), speciocilliatine (SPC), corynantheidine (COR), 7-hydroxymitragynine (7HMG) and paynantheine (PAY) was evaluated using human liver microsomes (HLMs) to understand their drug-drug interaction potentia...

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Vydáno v:Toxicol Lett
Hlavní autoři: Kamble, Shyam H., Sharma, Abhisheak, King, Tamara I., Berthold, Erin C., León, Francisco, Meyer, P. Katharina L., Kanumuri, Siva Rama Raju, McMahon, Lance R., McCurdy, Christopher R., Avery, Bonnie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902086/
https://ncbi.nlm.nih.gov/pubmed/31707106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2019.11.005
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