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A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide
R-loops are three-stranded nucleic acid structures with essential roles in many nuclear processes. However, their unchecked accumulation is associated with genome instability and is observed in neurodevelopmental diseases and cancers. Genome-wide profiling of R-loops in normal and diseased cells can...
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| Publié dans: | eLife |
|---|---|
| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7901872/ https://ncbi.nlm.nih.gov/pubmed/33620319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65146 |
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