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Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach

R-loops are three-stranded DNA:RNA hybrids that are implicated in many nuclear processes. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in neurological disorders and cancers. Current methods to assess their genome-wide distribution rely on af...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Yan, Qingqing, Shields, Emily J., Bonasio, Roberto, Sarma, Kavitha
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6870988/
https://ncbi.nlm.nih.gov/pubmed/31665646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.052
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