Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by another group. We review the anion CA inhibitors (...

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Bibliografische gegevens
Gepubliceerd in:J Enzyme Inhib Med Chem
Hoofdauteurs: Nocentini, Alessio, Angeli, Andrea, Carta, Fabrizio, Winum, Jean-Yves, Zalubovskis, Raivis, Carradori, Simone, Capasso, Clemente, Donald, William A., Supuran, Claudiu T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2021
Onderwerpen:
Review Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901698/
https://ncbi.nlm.nih.gov/pubmed/33615947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1882453
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