Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by another group. We review the anion CA inhibitors (...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Nocentini, Alessio, Angeli, Andrea, Carta, Fabrizio, Winum, Jean-Yves, Zalubovskis, Raivis, Carradori, Simone, Capasso, Clemente, Donald, William A., Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901698/
https://ncbi.nlm.nih.gov/pubmed/33615947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1882453
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