Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

[Image: see text] A new class of pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles was synthesized for the treatment of hyperproliferative pathologies, including neoplasms. The new compounds were screened in the 60 human cancer cell lines of the NCI drug screen and showed potent activity with GI(50)...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Spanò, Virginia, Rocca, Roberta, Barreca, Marilia, Giallombardo, Daniele, Montalbano, Alessandra, Carbone, Anna, Raimondi, Maria Valeria, Gaudio, Eugenio, Bortolozzi, Roberta, Bai, Ruoli, Tassone, Pierfrancesco, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Bertoni, Francesco, Barraja, Paola
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2020
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901646/
https://ncbi.nlm.nih.gov/pubmed/32986419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01315
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