Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

[Image: see text] A new class of pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles was synthesized for the treatment of hyperproliferative pathologies, including neoplasms. The new compounds were screened in the 60 human cancer cell lines of the NCI drug screen and showed potent activity with GI(50)...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Spanò, Virginia, Rocca, Roberta, Barreca, Marilia, Giallombardo, Daniele, Montalbano, Alessandra, Carbone, Anna, Raimondi, Maria Valeria, Gaudio, Eugenio, Bortolozzi, Roberta, Bai, Ruoli, Tassone, Pierfrancesco, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Bertoni, Francesco, Barraja, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901646/
https://ncbi.nlm.nih.gov/pubmed/32986419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01315
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