Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral Bioavailability Using Box-Behnken Design

PURPOSE: To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed. METHODS: Surfactants and solid carriers were screened based on a solubility and a flowability test, respectively. Supersaturating agents, including Poloxamer 407 (P407), were...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Goo, Yoon Tae, Sa, Cheol-Ki, Choi, Ji Yeh, Kim, Min Song, Kim, Chang Hyun, Kim, Hyeon Kyun, Choi, Young Wook
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2021
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901570/
https://ncbi.nlm.nih.gov/pubmed/33633449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S298450
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