How GPCR phosphorylation patterns orchestrate arrestin-mediated signaling

Binding of arrestin to phosphorylated G-protein-coupled receptors (GPCRs) controls many aspects of cell signaling. The number and arrangement of phosphates may vary substantially for a given GPCR, and different phosphorylation patterns trigger different arrestin-mediated effects. Here, we determine...

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Pubblicato in:Cell
Autori principali: Latorraca, Naomi R., Masureel, Matthieu, Hollingsworth, Scott A., Heydenreich, Franziska M., Suomivuori, Carl-Mikael, Brinton, Connor, Townshend, Raphael J.L., Bouvier, Michel, Kobilka, Brian K., Dror, Ron O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901245/
https://ncbi.nlm.nih.gov/pubmed/33296703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.014
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