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Molecular mechanism of GPCR-mediated arrestin activation
Despite intense interest in discovering drugs that cause G-protein-coupled receptors (GPCRs) to selectively stimulate or block arrestin signalling, the structural mechanism of receptor-mediated arrestin activation remains unclear(1,2). Here we reveal this mechanism through extensive atomic-level sim...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294333/ https://ncbi.nlm.nih.gov/pubmed/29720655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0077-3 |
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