Chromosomally unstable tumor cells specifically require KIF18A for proliferation

Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells may respond differently than diploid cells to treatments that target mitotic spindle regulation. Here, we test this idea by in...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Marquis, Carolyn, Fonseca, Cindy L., Queen, Katelyn A., Wood, Lisa, Vandal, Sarah E., Malaby, Heidi L. H., Clayton, Joseph E., Stumpff, Jason
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900194/
https://ncbi.nlm.nih.gov/pubmed/33619254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21447-2
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