Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model

Background: Esophageal adenocarcinoma (EAC) is a deadly disease with limited treatment options. STING is a transmembrane protein that activates transcription of interferon genes, resulting in stimulation of APCs and enhanced CD8+ T-cell infiltration. The present study evaluates STING agonists, alone...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zaidi, Ali H., Kelly, Ronan J., Gorbunova, Anastasia, Omstead, Ashten N., Salvitti, Madison S., Zheng, Ping, Kosovec, Juliann E., Lee, Soyoung, Ayazi, Shahin, Babar, Laila, Finley, Gene G., Goel, Ajay, Jobe, Blair A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899550/
https://ncbi.nlm.nih.gov/pubmed/33659041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27886
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