501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

We generated several versions of the receptor binding domain (RBD) of the Spike protein with mutations existing within newly emerging variants from South Africa and Brazil. We found that the mutant RBD with K417N, E484K, and N501Y exchanges has higher binding affinity to the human receptor compared...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Liu, Haolin, Wei, Pengcheng, Zhang, Qianqian, Chen, Zhongzhou, Aviszus, Katja, Downing, Walter, Peterson, Shelley, Reynoso, Lyndon, Downey, Gregory P., Frankel, Stephen K., Kappler, John, Marrack, Philippa, Zhang, Gongyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899443/
https://ncbi.nlm.nih.gov/pubmed/33619479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.16.431305
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