Rapid and Selective Chemical Editing of Ribosomally Synthesized and Post‐Translationally Modified Peptides (RiPPs) via Cu(II)‐Catalyzed β‐Borylation of Dehydroamino Acids

We report the fast and selective chemical editing of ribosomally synthesized and post‐translationally modified peptides (RiPPs) by β‐borylation of dehydroalanine (Dha) residues. The thiopeptide thiostrepton was modified efficiently using Cu(II)‐catalysis under mild conditions and 1D/2D NMR of the pu...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: de Vries, Reinder H., Viel, Jakob H., Kuipers, Oscar P., Roelfes, Gerard
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898795/
https://ncbi.nlm.nih.gov/pubmed/33185967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011460
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