Rapid and Selective Chemical Editing of Ribosomally Synthesized and Post‐Translationally Modified Peptides (RiPPs) via Cu(II)‐Catalyzed β‐Borylation of Dehydroamino Acids

We report the fast and selective chemical editing of ribosomally synthesized and post‐translationally modified peptides (RiPPs) by β‐borylation of dehydroalanine (Dha) residues. The thiopeptide thiostrepton was modified efficiently using Cu(II)‐catalysis under mild conditions and 1D/2D NMR of the pu...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: de Vries, Reinder H., Viel, Jakob H., Kuipers, Oscar P., Roelfes, Gerard
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898795/
https://ncbi.nlm.nih.gov/pubmed/33185967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011460
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