Selective Modification of Ribosomally Synthesized and Post‐Translationally Modified Peptides (RiPPs) through Diels–Alder Cycloadditions on Dehydroalanine Residues

We report the late‐stage chemical modification of ribosomally synthesized and post‐translationally modified peptides (RIPPs) by Diels–Alder cycloadditions to naturally occurring dehydroalanines. The tail region of the thiopeptide thiostrepton could be modified selectively and efficiently under micro...

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Udgivet i:Chemistry
Main Authors: de Vries, Reinder H., Viel, Jakob H., Oudshoorn, Ruben, Kuipers, Oscar P., Roelfes, Gerard
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790694/
https://ncbi.nlm.nih.gov/pubmed/31361053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902907
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