Selective Modification of Ribosomally Synthesized and Post‐Translationally Modified Peptides (RiPPs) through Diels–Alder Cycloadditions on Dehydroalanine Residues

We report the late‐stage chemical modification of ribosomally synthesized and post‐translationally modified peptides (RIPPs) by Diels–Alder cycloadditions to naturally occurring dehydroalanines. The tail region of the thiopeptide thiostrepton could be modified selectively and efficiently under micro...

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Dades bibliogràfiques
Publicat a:Chemistry
Autors principals: de Vries, Reinder H., Viel, Jakob H., Oudshoorn, Ruben, Kuipers, Oscar P., Roelfes, Gerard
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790694/
https://ncbi.nlm.nih.gov/pubmed/31361053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902907
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