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Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity

The l‐lysine‐ϵ‐dehydrogenase (LysEDH) from Geobacillus stearothermophilus naturally catalyzes the oxidative deamination of the ϵ‐amino group of l‐lysine. We previously engineered this enzyme to create amine dehydrogenase (AmDH) variants that possess a new hydrophobic cavity in their active site such...

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Bibliografski detalji
Izdano u:Chemistry
Glavni autori: Tseliou, Vasilis, Schilder, Don, Masman, Marcelo F., Knaus, Tanja, Mutti, Francesco G.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898336/
https://ncbi.nlm.nih.gov/pubmed/33073866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003140
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