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Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity

The l‐lysine‐ϵ‐dehydrogenase (LysEDH) from Geobacillus stearothermophilus naturally catalyzes the oxidative deamination of the ϵ‐amino group of l‐lysine. We previously engineered this enzyme to create amine dehydrogenase (AmDH) variants that possess a new hydrophobic cavity in their active site such...

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Bibliografiske detaljer
Udgivet i:Chemistry
Main Authors: Tseliou, Vasilis, Schilder, Don, Masman, Marcelo F., Knaus, Tanja, Mutti, Francesco G.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898336/
https://ncbi.nlm.nih.gov/pubmed/33073866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003140
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