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Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase

Amine dehydrogenases (AmDHs) catalyse the conversion of ketones into enantiomerically pure amines at the sole expense of ammonia and hydride source. Guided by structural information from computational models, we create AmDHs that can convert pharmaceutically relevant aromatic ketones with conversion...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tseliou, Vasilis, Knaus, Tanja, Masman, Marcelo F., Corrado, Maria L., Mutti, Francesco G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697735/
https://ncbi.nlm.nih.gov/pubmed/31420547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11509-x
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