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A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage
DNA double-strand breaks (DSBs) at ribosomal gene loci trigger inhibition of ribosomal DNA (rDNA) transcription and extensive nucleolar reorganization, including the formation of nucleolar caps where rDNA DSBs engage with canonical DSB signaling and repair factors. While these nucleolar responses un...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897492/ https://ncbi.nlm.nih.gov/pubmed/33469661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1290 |
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