Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

BACKGROUND: Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the CNS such...

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Bibliografiska uppgifter
I publikationen:J Neuroinflammation
Huvudupphovsmän: Hélie, Pauline, Camacho-Toledano, Celia, Lesec, Léonie, Seillier, Célia, Miralles, Antonio J., Ortega, Maria Cristina, Guérit, Sylvaine, Lebas, Héloïse, Bardou, Isabelle, Vila-del Sol, Virginia, Vivien, Denis, Le Mauff, Brigitte, Clemente, Diego, Docagne, Fabian, Toutirais, Olivier
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2021
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897384/
https://ncbi.nlm.nih.gov/pubmed/33610187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02102-5
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