Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

BACKGROUND: Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the CNS such...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Neuroinflammation
Main Authors: Hélie, Pauline, Camacho-Toledano, Celia, Lesec, Léonie, Seillier, Célia, Miralles, Antonio J., Ortega, Maria Cristina, Guérit, Sylvaine, Lebas, Héloïse, Bardou, Isabelle, Vila-del Sol, Virginia, Vivien, Denis, Le Mauff, Brigitte, Clemente, Diego, Docagne, Fabian, Toutirais, Olivier
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897384/
https://ncbi.nlm.nih.gov/pubmed/33610187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02102-5
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