Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

BACKGROUND: Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the CNS such...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Hélie, Pauline, Camacho-Toledano, Celia, Lesec, Léonie, Seillier, Célia, Miralles, Antonio J., Ortega, Maria Cristina, Guérit, Sylvaine, Lebas, Héloïse, Bardou, Isabelle, Vila-del Sol, Virginia, Vivien, Denis, Le Mauff, Brigitte, Clemente, Diego, Docagne, Fabian, Toutirais, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897384/
https://ncbi.nlm.nih.gov/pubmed/33610187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02102-5
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