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ER-directed TREX1 limits cGAS activation at micronuclei
Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-segregation. Frequent loss of micronuclear envelope integrity exposes DNA to the cytoplasm, leading to chromosome fragmentation and immune activation. Here, we use micronuclei purification to show that the endo...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897315/ https://ncbi.nlm.nih.gov/pubmed/33476576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.037 |
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