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Quantile-specific heritability of total cholesterol and its pharmacogenetic and nutrigenetic implications
BACKGROUND: “Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. cholesterol) is high or low relative to its distribution. We have previously shown that the effect of a 52-SNP genetic-risk score was 3-fold larger at the 90th perc...
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| Publicado no: | Int J Cardiol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897293/ https://ncbi.nlm.nih.gov/pubmed/33296721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2020.11.070 |
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