Tau induces PSD95-nNOS uncoupling and neurovascular dysfunction independent of neurodegeneration

Cerebrovascular abnormalities have emerged as a preclinical manifestation of Alzheimer’s disease and frontotemporal dementia, diseases characterized by accumulation of hyperphosphorylated forms of the microtubule associated protein tau. However, it is unclear if tau contributes to these neurovascula...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Park, Laibaik, Hochrainer, Karin, Hattori, Yorito, Ahn, Sung Ji, Anfray, Antoine, Wang, Gang, Uekawa, Ken, Seo, James, Palfini, Victoria, Blanco, Ismary, Acosta, Diana, Eliezer, David, Zhou, Ping, Anrather, Josef, Iadecola, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896353/
https://ncbi.nlm.nih.gov/pubmed/32778793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0686-7
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