Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice

Post-zygotic mutations that generate tissue mosaicism are increasingly associated with severe congenital defects, including those arising from failed neural tube closure. Here we report that neural fold elevation during mouse spinal neurulation is vulnerable to deletion of the VANGL planar cell pola...

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Udgivet i:Nat Commun
Main Authors: Galea, Gabriel L., Maniou, Eirini, Edwards, Timothy J., Marshall, Abigail R., Ampartzidis, Ioakeim, Greene, Nicholas D. E., Copp, Andrew J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895924/
https://ncbi.nlm.nih.gov/pubmed/33608529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21372-4
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