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Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies
We present a full-likelihood method to infer polygenic adaptation from DNA sequence variation and GWAS summary statistics to quantify recent transient directional selection acting on a complex trait. Through simulations of polygenic trait architecture evolution and GWASs, we show the method substant...
Gardado en:
| Publicado en: | Am J Hum Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7895848/ https://ncbi.nlm.nih.gov/pubmed/33440170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.12.005 |
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