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A model and test for coordinated polygenic epistasis in complex traits
Interactions between genetic variants—epistasis—is pervasive in model systems and can profoundly impact evolutionary adaption, population disease dynamics, genetic mapping, and precision medicine efforts. In this work, we develop a model for structured polygenic epistasis, called coordinated epistas...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8053945/ https://ncbi.nlm.nih.gov/pubmed/33833052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922305118 |
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