Loading...

Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant

As a key regulator of the tumour suppressor protein p53, MDM2 is involved in various types of cancer and has thus been an attractive drug target. So far, small molecule design has primarily focussed on the N-terminal p53-binding domain although on-target toxicity effects have been reported. Targetin...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Mol Biol
Main Authors: Magnussen, Helge M., Huang, Danny T.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895813/
https://ncbi.nlm.nih.gov/pubmed/33450248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166807
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!