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Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant
As a key regulator of the tumour suppressor protein p53, MDM2 is involved in various types of cancer and has thus been an attractive drug target. So far, small molecule design has primarily focussed on the N-terminal p53-binding domain although on-target toxicity effects have been reported. Targetin...
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| Foilsithe in: | J Mol Biol |
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| Main Authors: | , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Elsevier
2021
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7895813/ https://ncbi.nlm.nih.gov/pubmed/33450248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166807 |
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