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The catalytic mechanism of vitamin K epoxide reduction in a cellular environment

Vitamin K epoxide reductases (VKORs) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully red...

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Foilsithe in:J Biol Chem
Main Authors: Shen, Guomin, Cui, Weidong, Cao, Qing, Gao, Meng, Liu, Hongli, Su, Gaigai, Gross, Michael L., Li, Weikai
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895805/
https://ncbi.nlm.nih.gov/pubmed/33273012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015401
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