PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser(114) phosphorylation

Mutations in the PRKACA gene are the most frequent cause of cortisol-producing adrenocortical adenomas leading to Cushing’s syndrome. PRKACA encodes for the catalytic subunit α of protein kinase A (PKA). We already showed that PRKACA mutations lead to impairment of regulatory (R) subunit binding. Fu...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Weigand, Isabel, Ronchi, Cristina L., Vanselow, Jens T., Bathon, Kerstin, Lenz, Kerstin, Herterich, Sabine, Schlosser, Andreas, Kroiss, Matthias, Fassnacht, Martin, Calebiro, Davide, Sbiera, Silviu
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895437/
https://ncbi.nlm.nih.gov/pubmed/33608270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd4176
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