Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas

Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA is a stable and inactive heterotetramer, consisting of two cat...

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Publicado en:Sci Rep
Autores principales: Weigand, Isabel, Ronchi, Cristina L., Rizk-Rabin, Marthe, Dalmazi, Guido Di, Wild, Vanessa, Bathon, Kerstin, Rubin, Beatrice, Calebiro, Davide, Beuschlein, Felix, Bertherat, Jérôme, Fassnacht, Martin, Sbiera, Silviu
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427838/
https://ncbi.nlm.nih.gov/pubmed/28250426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00125-8
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