Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PL(pro)) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Welker, Armin, Kersten, Christian, Müller, Christin, Madhugiri, Ramakanth, Zimmer, Collin, Müller, Patrick, Zimmermann, Robert, Hammerschmidt, Stefan, Maus, Hannah, Ziebuhr, John, Sotriffer, Christoph, Schirmeister, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894572/
https://ncbi.nlm.nih.gov/pubmed/32930481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000548
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