Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PL(pro)) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Welker, Armin, Kersten, Christian, Müller, Christin, Madhugiri, Ramakanth, Zimmer, Collin, Müller, Patrick, Zimmermann, Robert, Hammerschmidt, Stefan, Maus, Hannah, Ziebuhr, John, Sotriffer, Christoph, Schirmeister, Tanja
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894572/
https://ncbi.nlm.nih.gov/pubmed/32930481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000548
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