Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PL(pro)) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ChemMedChem
Päätekijät: Welker, Armin, Kersten, Christian, Müller, Christin, Madhugiri, Ramakanth, Zimmer, Collin, Müller, Patrick, Zimmermann, Robert, Hammerschmidt, Stefan, Maus, Hannah, Ziebuhr, John, Sotriffer, Christoph, Schirmeister, Tanja
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Full Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894572/
https://ncbi.nlm.nih.gov/pubmed/32930481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000548
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