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Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48
The scaffolding protein RbAp48 is part of several epigenetic regulation complexes and is overexpressed in a variety of cancers. In order to develop tool compounds for the study of RbAp48 function, we have developed peptide inhibitors targeting the protein–protein interaction interface between RbAp48...
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| Pubblicato in: | Angew Chem Int Ed Engl |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7894522/ https://ncbi.nlm.nih.gov/pubmed/33022847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202009749 |
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